ncRNA name | GNAQ siRNA |
ncRNA Category | siRNA |
Disease name | uveal melanoma (UM) |
Species | Homo sapiens |
Tissues/Cell_line | UM cell lines OCM1, OMM2.3 and 92.1 |
Methods | siRNA transfection, qPCR, CCK-8 assay, Western blot, annexin-V and PI staining |
Expression pattern | associated |
Functional description | Combined treatment of siGNAQ and H101 inhibited the proliferation and activated the apoptosis of OMM2.3 and 92.1 cells by blocking the phosphorylation of MEK1/2 and increasing the phosphorylation of YAP. |
PubMed ID | 30320917 |
Year | 2019 |
Title | The oncolytic virus H101 combined with GNAQ siRNA-mediated knockdown reduces uveal melanoma cell viability. |
Drug-related ncRNA | NO |
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